Safe, Effective, Natural, and Working to Save Lives

How Can Tocotrienols Help?

Our extraction process is remarkable, not just because of the purity of the product it creates, but also because of the range of purified isoforms it can generate. Each of these isoforms has unique properties and treatment applications.

Our ability to manufacture and distribute various isoform formulations ensures the highest quality and uniformity across applications and treatment courses.  Here are a few of the most promising research programs and clinical trials H&G Science is currently involved in.


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Radiation Damage Prevention

We are involved in discussions with a leading rectal cancer specialist at a major research institution who has conducted his own animal studies and seen the exciting radio-protectant properties of tocotrienols first-hand. Having personally witnessed the permanent, life altering damage caused by radiation therapy to thousands of patients, he believes this will have a great positive impact on both the success of the treatment and the quality of life for survivors. He has also demonstrated that tocotrienols, while protecting healthy cells from the harms of ionizing radiation, act to sensitize tumors to radiation treatments.  

He has submitted a proposal to team with us and perform a formal clinical trial with his patients to demonstrate the radiation-sensitizing effect of gamma-tocotrienol on colon cancer tumors. This provides an exciting opportunity to treat cancer patients with tocotrienol, as pre-clinical data suggests that tocotrienol treatment may also cause tumor shrinkage. 

Any clinical trial data will be used to facilitate further research and business opportunities. Our goal is to design the clinical trial so useful data will be obtained regarding potential tumor shrinkage during the pre-radiation gamma-tocotrienol regimen, potential protection of healthy tissue when gamma-tocotrienol is administered before the radiation procedure, and the primary focus of enhanced tumor sensitivity to radiation treatment when gamma-tocotrienol has been administered and accumulated in the tumor.

 
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Radiation Protection


We have received a formal proposal to run Phase I/II human clinical trials on tocotrienol as a radiation protection agent for patients undergoing cardiac imaging procedures and the interventionalists performing the procedures.

This particular opportunity paves the way to directly market an over-the-counter supplement to everyday consumers for protection against environmental radiation, as well as a more targeted single or double-dose regimen for patients undergoing these radiation intensive procedures. 

The initial target market will be practitioners and patients of the procedure, with expected expansion into a consumer over-the-counter health supplement business in the years to follow.


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Cancer Treatment

One of the leading cancer research institutes, under the direction of the gastrointestinal oncology department leader, is ready to enter Phase Ib/II clinical trials on the use of delta-tocotrienol for the prevention of pancreatic cancer metastasis after surgical tumor removal.  

They have recently received supplemental funding from a pharmaceutical company to initiate the clinical research. Compelling pre-clinical data has shown that delta-tocotrienol, when administered alongside the current standard of care, dramatically decreases the risk of pancreatic cancer recurrence in patients who have undergone tumor removal and colon resection surgery. 

Further data indicates that when administered as a maintenance dose, tocotrienol can delay or eliminate relapse in treated patients. This partner has submitted a proposal to team with us to perform a formal clinical trial to treat patients for a minimum of one year, with daily doses of delta-tocotrienol. We are currently in discussions with the sponsor pharmaceutical company to supply the tocotrienol for their trials.

 
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Stroke Prevention

Alpha-tocotrienol is the only isoform known to cross the blood-brain barrier. Studies performed at a leading research university on small animals have shown that tocotrienols act to prevent permanent damage caused by stroke and head trauma. 

H&G Science provided some of the tocotrienol material used in the research and has maintained contact with the researchers, who have left the institution and moved on to other areas of study.  There is an opportunity to continue this work at another institution and ultimately run clinical trials to demonstrate the effectiveness of tocotrienols in preventing brain damage and swelling in humans. 

The potential market arising from positive data is quite significant. Having a supplement to protect against damage from head trauma would transform professional contact sports where head injuries are prevalent. Further, a supplement to protect against brain swelling has potential applications toward many brain-related diseases and acute conditions including depression.